Activin receptor

Activin types I and II receptor domain

Identifiers

Symbol

Activin_recp

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

An Activin receptor is a receptor which binds activin.

Types include:

These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain^[1]^[2]^[3].

Human proteins containing this domain

^ Wrana JL, Attisano L (1996). "Signal transduction by members of the transforming growth factor-beta superfamily". Cytokine Growth Factor Rev. 7 (4): 327–339. doi:10.1016/S1359-6101(96)00042-1. PMID 9023056.
^ Wrana JL, Attisano L, Wieser R, Ventura F, Massague J (1994). "Mechanism of activation of the TGF-beta receptor". Nature 370 (6488): 341–347. doi:10.1038/370341a0. PMID 8047140.
^ Massague J, Weis-Garcia F (1996). "Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals". Cancer Surv. 27: 41–64. PMID 8909794.

Receptors: growth factor receptors

Type I cytokine receptor	Nerve growth factors: Ciliary neurotrophic factor Erythropoietin

Receptor protein serine/threonine kinase	TGF pathway: TGF-beta (1, 2) · Activin (1, 2) · Bone morphogenetic protein (1, 2)

Receptor tyrosine kinase	Fibroblast growth factor (1, 2, 3, 4) Nerve growth factors: high affinity Trk (TrkA, TrkB, TrkC) Hepatocyte growth factor Somatomedin (Insulin-like growth factor 1) ErbB/Epidermal growth factor VEGF (1, 2, 3)

Tumor necrosis factor receptor	Nerve growth factors: Low affinity/p75

Ig superfamily	Platelet-derived growth factor (A, B) Stem cell factor

Other/ungrouped	Somatomedin (Insulin-like growth factor 2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Cell signaling: TGF beta signaling pathway

TGF beta superfamily of ligands	TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin and inhibin, Anti-müllerian hormone, Nodal)

TGF beta receptors (Activin, BMP)	TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) · ACVRL1 · BMPR1 (BMPR1A · BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) · AMHR2 · BMPR2 TGFBR3: betaglycan

Transducers/SMAD	R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) · I-SMAD (SMAD6, SMAD7) · SMAD4

Ligand inhibitors	Cerberus · Chordin · DAN · Decorin · Follistatin · Gremlin · Lefty · LTBP1 · Noggin · THBS1

Coreceptors	BAMBI · Cripto

Other	SARA

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

This article incorporates text from the public domain Pfam and InterPro IPR000472